Oxaprozin

An orally administered nonsteroidal anti-inflammatory drug used for the symptomatic treatment of osteoarthritis and rheumatoid arthritis, including juvenile rheumatoid arthritis in selected patients. Oxaprozin inhibits cyclooxygenase enzymes (COX-1 and COX-2), reducing prostaglandin biosynthesis and thereby alleviating inflammation, pain, and swelling. It has a relatively long elimination half-life, allowing once-daily dosing in many patients. Like other NSAIDs, it carries risks of gastrointestinal bleeding, renal impairment, and cardiovascular adverse events

Compound Structure

CAS Number: 21256-18-8

Molecular Mass: 293.3 g/mol

Formula: C18H15NO3

Smiles: O=C(O)CCc1nc(-c2ccccc2)c(-c2ccccc2)o1

Synonymes:

Bioactivity: Nonsteroidal anti-inflammatory drug (NSAID); nonselective cyclooxygenase-1 and cyclooxygenase-2 (COX-1/COX-2) inhibitor

Solubility in Different Solvents

Solvent Temperature [K] Crystal form Solubility [mg/mL] Reference
1-Butanol 278.15 - 8.665 [121]
1-Butanol 283.15 - 10.64 [121]
1-Butanol 288.15 - 13.64 [121]
1-Butanol 293.15 - 17.17 [121]
1-Butanol 298.15 - 21.28 [121]
1-Butanol 303.15 - 26.0 [121]
1-Butanol 308.15 - 33.42 [121]
1-Butanol 313.15 - 41.6 [121]
1-Butanol 318.15 - 52.03 [121]
1-Butanol 323.15 - 65.09 [121]
1-Pentanol 278.15 - 7.327 [121]
1-Pentanol 283.15 - 9.578 [121]
1-Pentanol 288.15 - 12.53 [121]
1-Pentanol 293.15 - 15.29 [121]
1-Pentanol 298.15 - 19.05 [121]
1-Pentanol 303.15 - 23.41 [121]
1-Pentanol 308.15 - 29.17 [121]
1-Pentanol 313.15 - 36.23 [121]
1-Pentanol 318.15 - 45.24 [121]
1-Pentanol 323.15 - 56.51 [121]
1-Propanol 278.15 - 10.18 [121]
1-Propanol 283.15 - 12.96 [121]
1-Propanol 288.15 - 16.38 [121]
1-Propanol 293.15 - 20.46 [121]
1-Propanol 298.15 - 25.02 [121]
1-Propanol 303.15 - 31.08 [121]
1-Propanol 308.15 - 39.0 [121]
1-Propanol 313.15 - 47.51 [121]
1-Propanol 318.15 - 62.44 [121]
1-Propanol 323.15 - 78.04 [121]
Amyl Acetate 278.15 - 5.535 [121]
Amyl Acetate 283.15 - 6.643 [121]
Amyl Acetate 288.15 - 7.736 [121]
Amyl Acetate 293.15 - 9.14 [121]
Amyl Acetate 298.15 - 10.9 [121]
Amyl Acetate 303.15 - 12.85 [121]
Amyl Acetate 308.15 - 15.28 [121]
Amyl Acetate 313.15 - 18.11 [121]
Amyl Acetate 318.15 - 21.56 [121]
Amyl Acetate 323.15 - 25.5 [121]
Butyl acetate 278.15 - 6.639 [121]
Butyl acetate 283.15 - 7.825 [121]
Butyl acetate 288.15 - 9.337 [121]
Butyl acetate 293.15 - 10.93 [121]
Butyl acetate 298.15 - 13.19 [121]
Butyl acetate 303.15 - 15.65 [121]
Butyl acetate 308.15 - 18.57 [121]
Butyl acetate 313.15 - 22.08 [121]
Butyl acetate 318.15 - 26.25 [121]
Butyl acetate 323.15 - 31.14 [121]
Dimethyl sulfoxide 293.15 - 1123.9 [121]
Dimethyl sulfoxide 298.15 - 1198.3 [121]
Dimethyl sulfoxide 303.15 - 1292.8 [121]
Dimethyl sulfoxide 308.15 - 1405.1 [121]
Dimethyl sulfoxide 313.15 - 1515.9 [121]
Dimethyl sulfoxide 318.15 - 1624.7 [121]
Dimethyl sulfoxide 323.15 - 1748.6 [121]
Dimethylacetamide 278.15 - 830.4 [121]
Dimethylacetamide 283.15 - 865.1 [121]
Dimethylacetamide 288.15 - 911.6 [121]
Dimethylacetamide 293.15 - 956.0 [121]
Dimethylacetamide 298.15 - 1010.5 [121]
Dimethylacetamide 303.15 - 1055.4 [121]
Dimethylacetamide 308.15 - 1104.1 [121]
Dimethylacetamide 313.15 - 1167.7 [121]
Dimethylacetamide 318.15 - 1223.9 [121]
Dimethylacetamide 323.15 - 1286.0 [121]
Dimethylformamide 278.15 - 608.6 [121]
Dimethylformamide 283.15 - 655.3 [121]
Dimethylformamide 288.15 - 698.5 [121]
Dimethylformamide 293.15 - 745.7 [121]
Dimethylformamide 298.15 - 798.6 [121]
Dimethylformamide 303.15 - 860.4 [121]
Dimethylformamide 308.15 - 922.5 [121]
Dimethylformamide 313.15 - 971.4 [121]
Dimethylformamide 318.15 - 1037.9 [121]
Dimethylformamide 323.15 - 1112.0 [121]
Ethanol 278.15 - 13.17 [121]
Ethanol 283.15 - 16.05 [121]
Ethanol 288.15 - 19.67 [121]
Ethanol 293.15 - 24.04 [121]
Ethanol 298.15 - 29.78 [121]
Ethanol 303.15 - 35.85 [121]
Ethanol 308.15 - 44.59 [121]
Ethanol 313.15 - 55.48 [121]
Ethanol 318.15 - 69.29 [121]
Ethanol 323.15 - 87.6 [121]
Ethyl acetate 278.15 - 12.22 [121]
Ethyl acetate 283.15 - 14.41 [121]
Ethyl acetate 288.15 - 16.93 [121]
Ethyl acetate 293.15 - 19.95 [121]
Ethyl acetate 298.15 - 23.35 [121]
Ethyl acetate 303.15 - 27.61 [121]
Ethyl acetate 308.15 - 32.63 [121]
Ethyl acetate 313.15 - 37.98 [121]
Ethyl acetate 318.15 - 44.26 [121]
Ethyl acetate 323.15 - 52.08 [121]
Methanol 278.15 - 17.0 [121]
Methanol 283.15 - 20.72 [121]
Methanol 288.15 - 25.07 [121]
Methanol 293.15 - 30.98 [121]
Methanol 298.15 - 37.84 [121]
Methanol 303.15 - 47.32 [121]
Methanol 308.15 - 58.87 [121]
Methanol 313.15 - 73.63 [121]
Methanol 318.15 - 92.23 [121]
Methanol 323.15 - 116.7 [121]
Methyl acetate 278.15 - 20.22 [121]
Methyl acetate 283.15 - 23.62 [121]
Methyl acetate 288.15 - 27.56 [121]
Methyl acetate 293.15 - 32.33 [121]
Methyl acetate 298.15 - 37.84 [121]
Methyl acetate 303.15 - 44.26 [121]
Methyl acetate 308.15 - 53.49 [121]
Methyl acetate 313.15 - 61.18 [121]
Methyl acetate 318.15 - 69.73 [121]
Methyl acetate 323.15 - 79.6 [121]
Propyl acetate 278.15 - 8.35 [121]
Propyl acetate 283.15 - 10.01 [121]
Propyl acetate 288.15 - 11.94 [121]
Propyl acetate 293.15 - 13.7 [121]
Propyl acetate 298.15 - 16.74 [121]
Propyl acetate 303.15 - 19.83 [121]
Propyl acetate 308.15 - 23.62 [121]
Propyl acetate 313.15 - 27.91 [121]
Propyl acetate 318.15 - 33.07 [121]
Propyl acetate 323.15 - 39.35 [121]

Molecule 3D descriptors

Descriptor Value
PMI1 1437.9751
PMI2 3147.0620
PMI3 4299.4876
NPR1 0.3345
NPR2 0.7320
RadiusOfGyration 3.8916
InertialShapeFactor 0.0005
Eccentricity 0.9424
Asphericity 0.3151
SpherocityIndex 0.1447
PBF 0.7872