Bezafibrate

An orally administered lipid-lowering agent used to treat hypertriglyceridemia and mixed dyslipidemia. Bezafibrate activates peroxisome proliferator-activated receptors (PPARs), particularly PPARα, promoting fatty acid oxidation, enhancing triglyceride-rich lipoprotein clearance, and reducing hepatic triglyceride production. It lowers plasma triglyceride concentrations, can moderately reduce LDL cholesterol, and may increase HDL cholesterol. Bezafibrate is used primarily when triglyceride reduction is clinically indicated, with attention to potential muscle toxicity and renal function

CAS Number: 41859-67-0

Molecular Mass: 361.8 g/mol

Formula: C₁₉H₂₀ClNO₄

Smiles: CC(C)(Oc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1)C(=O)O

Synonymes:

Bezafibrate, bezafibrate, 41859-67-0, Bezalip, Bezafibrato, Bezatol SR, Bezafibratum, BM-15.075, BM-15075, BM 15.075, DTXSID3029869, NSC-758174, Y9449Q51XH, Propanoic acid, 2-(4-(2-((4-chlorobenzoyl)amino)ethyl)phenoxy)-2-methyl-, DTXCID909869, CHEBI:47612, Propanoic acid, 2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methyl-, Beza Lande, Beza Puren, BM15.075, Bezalip-mono, Fibrazate xl, Zimbacol xl, Bezagen xl, Liparol xl, RefChem:58600, C10AB02, 255-567-9, Cedur, Befizal, Bezafibrat, Sklerofibrat, Azufibrat, Bezafibratum [INN-Latin], Bezafibrato [INN-Spanish], Bezatol SR (TN), 2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methylpropanoic acid, 2-(4-(2-(4-Chlorobenzamido)ethyl)phenoxy)-2-methylpropanoic acid, 2-(p-(2-(p-Chlorobenzamido)ethyl)phenoxy)-2-methylpropionic acid, MFCD00078970, Difaterol, Bezatol, 2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid, 2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methyl-propanoic acid, MLS000028533, CHEMBL264374, durabezur, Reducterol, Bezabeta, Bezacur, Bezamerck, Eulitop, Solibay, Lipox, Bezafibrat PB, Beza-Lande, Beza-Puren, Regadrin B, 2-(4-{2-[(4-chlorophenyl)formamido]ethyl}phenoxy)-2-methylpropanoic acid, BM15075, NCGC00016850-01, SMR000058298, Bezafibrato [Spanish], Bezalip Retard, CAS-41859-67-0, BF-759, 2-{4-[2-(4-chlorobenzamido)ethyl]phenoxy}-2-methylpropanoic acid, BM 15075, LO 44, 2-(4-{2-[(4-chlorobenzoyl)amino]ethyl}phenoxy)-2-methylpropanoic acid, 2-[P-[2-P-CHLOROBENZAMIDO)ETHYL]PHENOXY]-2-METHYLPROPIONIC ACID, CCRIS 9085, SR-01000000106, EINECS 255-567-9, BRN 4267656, UNII-Y9449Q51XH, Bezafibrate CRS, Bezalip SR, Bezafibrate [USAN:INN:BAN:JAN], PEM, Prestwick_724, BENAFIBRATE, a-[4-(4-chlorobenzoylaminoethyl)phenoxy]isobutyric acid, Bezafibrate (Standard), Spectrum_001443, Opera_ID_376, BEZAFIBRATE [MI], Prestwick0_000378, Prestwick1_000378, Prestwick2_000378, Prestwick3_000378, Spectrum2_000922, Spectrum3_001500, Spectrum4_000325, Spectrum5_001079, Spectrum5_001967, BEZAFIBRATE [INN], BEZAFIBRATE [JAN], BEZAFIBRATE [USAN], BEZAFIBRATE [MART.], SCHEMBL16299, BEZAFIBRATE [WHO-DD], BSPBio_000535, BSPBio_001314, BSPBio_003119, KBioGR_000034, KBioGR_000669, KBioSS_000034, KBioSS_001923, MLS001148205, Bezafibrate, >=98%, solid, DivK1c_000092, SPECTRUM1502046, SPBio_000824, SPBio_002456, BPBio1_000589, GTPL2668, orb1310243, orb3025853, Bezafibrate - Bio-X trade mark, BDBM28701, Bezafibrate (JP18/USAN/INN), HMS500E14, HY-B0637R, KBio1_000092, KBio2_000034, KBio2_001923, KBio2_002602, KBio2_004491, KBio2_005170, KBio2_007059, KBio3_000067, KBio3_000068, KBio3_002619, 2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]isobutyric Acid, NINDS_000092, BEZAFIBRATE [EP MONOGRAPH], Bio2_000034, Bio2_000514, HMS1361B16, HMS1569K17, HMS1791B16, HMS1921H16, HMS1989B16, HMS2089F04, HMS2092B12, HMS2096K17, HMS2233E22, HMS3261D21, HMS3369B13, HMS3402B16, HMS3650K22, HMS3652M22, HMS3713K17, HMS5082C22, Pharmakon1600-01502046, HY-B0637, MSK10345, UYB80274, Tox21_110645, Tox21_301845, Tox21_500500, CCG-39683, EBC-26794, NSC758174, s4159, AKOS005107743, Propionic acid, 2-(4-(2-((4-chlorobenzoyl)amino)ethyl)phenoxy)-2-methyl-, Tox21_110645_1, AB03023, AC-6817, DB01393, FB18580, HS-0040, LP00500, NSC 758174, SB17361, SDCCGSBI-0051715.P003, IDI1_000092, IDI1_033784, NCGC00016850-02, NCGC00016850-03, NCGC00016850-04, NCGC00016850-05, NCGC00016850-06, NCGC00016850-07, NCGC00016850-08, NCGC00016850-09, NCGC00016850-10, NCGC00016850-11, NCGC00016850-12, NCGC00016850-15, NCGC00016850-25, NCGC00023317-03, NCGC00023317-04, NCGC00023317-05, NCGC00023317-06, NCGC00023317-07, NCGC00023317-08, NCGC00255376-01, NCGC00261185-01, BB166159, Bezafibrate, analytical reference material, SY052507, Bezafibrate 100 microg/mL in Acetonitrile, SBI-0051715.P002, DB-238976, AB00052265, B3346, NS00000219, ST51014927, SW196871-4, D01366, D70191, AB00052265-15, AB00052265_16, AB00052265_17, EN300-18539646, F544300, Q577387, SR-01000000106-3, SR-01000000106-4, SR-01000000106-5, BRD-K46018455-001-06-0, BRD-K46018455-001-17-7, BRD-K46018455-001-26-8, BRD-K46018455-001-27-6, SR-01000000106-10, Bezafibrate Working Standard (Secondary Reference Standard), Bezafibrate, European Pharmacopoeia (EP) Reference Standard, 2-(4-(2-parachlorobenzamidoethyl)phenoxy)-2-methylpropionic acid, 2-[4-[2-(4-chlorobezamide)ethyl]phenoxy]-2-methylpropanoic acid, 2-[4-[2-[(4-Chlorobenzoyl)amino]ethyl]phenoxyl]-2-methylpropanoic Acid, 2-(4-{2-[(4-chlorophenyl)carbonylamino]ethyl}phenoxy)-2-methylpropanoic acid, 2-[4-(2-{[(4-chlorophenyl)carbonyl]amino}ethyl)phenoxy]-2-methylpropanoic acid

Bioactivity: Peroxisome proliferator-activated receptor (PPAR) agonist; hypolipidemic fibrate; modulator of lipid metabolism

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
1-Butanol	283.16	-	9.073	[120]
1-Butanol	288.17	-	10.74	[120]
1-Butanol	293.14	-	13.18	[120]
1-Butanol	298.17	-	15.91	[120]
1-Butanol	303.16	-	19.41	[120]
1-Butanol	308.14	-	23.48	[120]
1-Butanol	313.17	-	28.42	[120]
1-Butanol	318.16	-	34.29	[120]
1-Butanol	323.17	-	40.36	[120]
1-Pentanol	283.23	-	7.879	[120]
1-Pentanol	288.23	-	9.641	[120]
1-Pentanol	293.29	-	11.54	[120]
1-Pentanol	298.5	-	13.63	[120]
1-Pentanol	303.24	-	16.54	[120]
1-Pentanol	308.02	-	19.91	[120]
1-Pentanol	313.08	-	23.82	[120]
1-Pentanol	317.95	-	28.26	[120]
1-Pentanol	322.74	-	33.74	[120]
1-Propanol	283.13	-	11.71	[120]
1-Propanol	283.15	-	12.07	[119]
1-Propanol	288.15	-	14.47	[119]
1-Propanol	288.18	-	14.1	[120]
1-Propanol	293.15	-	17.54	[119]
1-Propanol	293.27	-	17.04	[120]
1-Propanol	298.15	-	21.13	[119]
1-Propanol	298.53	-	20.36	[120]
1-Propanol	303.15	-	25.25	[119]
1-Propanol	303.33	-	24.86	[120]
1-Propanol	308.15	-	30.24	[119]
1-Propanol	308.23	-	29.58	[120]
1-Propanol	313.15	-	35.49	[119]
1-Propanol	313.37	-	34.82	[120]
1-Propanol	318.15	-	41.89	[119]
1-Propanol	318.35	-	40.71	[120]
1-Propanol	323.15	-	48.1	[119]
1-Propanol	323.26	-	49.16	[120]
2-Butanol	283.16	-	9.184	[120]
2-Butanol	288.17	-	11.67	[120]
2-Butanol	293.14	-	14.43	[120]
2-Butanol	298.16	-	17.46	[120]
2-Butanol	303.16	-	20.76	[120]
2-Butanol	308.14	-	25.02	[120]
2-Butanol	313.17	-	29.74	[120]
2-Butanol	318.16	-	35.32	[120]
2-Butanol	323.16	-	40.84	[120]
Acetonitrile	283.24	-	0.7929	[120]
Acetonitrile	288.25	-	1.062	[120]
Acetonitrile	293.24	-	1.395	[120]
Acetonitrile	298.25	-	1.876	[120]
Acetonitrile	303.24	-	2.414	[120]
Acetonitrile	308.22	-	3.172	[120]
Acetonitrile	313.22	-	4.189	[120]
Acetonitrile	318.23	-	5.384	[120]
Acetonitrile	323.24	-	6.792	[120]
Butyl acetate	283.17	-	0.9075	[120]
Butyl acetate	288.19	-	1.106	[120]
Butyl acetate	293.2	-	1.356	[120]
Butyl acetate	298.14	-	1.716	[120]
Butyl acetate	303.19	-	2.116	[120]
Butyl acetate	308.16	-	2.559	[120]
Butyl acetate	313.14	-	3.047	[120]
Butyl acetate	318.14	-	3.696	[120]
Butyl acetate	323.2	-	4.448	[120]
Cyclohexanone	283.14	-	17.58	[120]
Cyclohexanone	288.19	-	21.37	[120]
Cyclohexanone	293.24	-	25.73	[120]
Cyclohexanone	298.14	-	31.23	[120]
Cyclohexanone	303.27	-	37.22	[120]
Cyclohexanone	308.13	-	44.41	[120]
Cyclohexanone	313.19	-	52.69	[120]
Cyclohexanone	318.22	-	61.43	[120]
Cyclohexanone	323.22	-	70.64	[120]
Ethanol	283.14	-	16.23	[120]
Ethanol	283.15	-	13.99	[119]
Ethanol	288.15	-	16.92	[119]
Ethanol	288.24	-	17.6	[120]
Ethanol	293.15	-	20.66	[119]
Ethanol	293.3	-	20.49	[120]
Ethanol	298.15	-	24.88	[119]
Ethanol	298.28	-	24.18	[120]
Ethanol	303.15	-	29.72	[119]
Ethanol	303.24	-	28.65	[120]
Ethanol	308.15	-	35.03	[119]
Ethanol	308.22	-	33.01	[120]
Ethanol	313.13	-	40.54	[120]
Ethanol	313.15	-	42.05	[119]
Ethanol	318.15	-	49.57	[119]
Ethanol	318.18	-	48.75	[120]
Ethanol	323.15	-	59.15	[119]
Ethanol	323.24	-	58.83	[120]
Ethyl acetate	283.17	-	2.09	[120]
Ethyl acetate	288.17	-	2.478	[120]
Ethyl acetate	293.16	-	2.92	[120]
Ethyl acetate	298.14	-	3.654	[120]
Ethyl acetate	303.17	-	4.398	[120]
Ethyl acetate	308.14	-	5.332	[120]
Ethyl acetate	313.17	-	6.406	[120]
Ethyl acetate	318.16	-	7.891	[120]
Ethyl acetate	323.19	-	9.328	[120]
Isoamyl Alcohol	283.77	-	4.992	[120]
Isoamyl Alcohol	288.56	-	6.532	[120]
Isoamyl Alcohol	293.5	-	8.246	[120]
Isoamyl Alcohol	298.59	-	10.06	[120]
Isoamyl Alcohol	303.13	-	12.03	[120]
Isoamyl Alcohol	308.21	-	14.86	[120]
Isoamyl Alcohol	313.25	-	18.16	[120]
Isoamyl Alcohol	318.17	-	21.91	[120]
Isoamyl Alcohol	323.25	-	26.57	[120]
Isobutanol	282.95	-	4.544	[120]
Isobutanol	288.04	-	5.902	[120]
Isobutanol	292.93	-	7.974	[120]
Isobutanol	298.24	-	10.15	[120]
Isobutanol	303.2	-	12.28	[120]
Isobutanol	308.22	-	15.32	[120]
Isobutanol	313.23	-	18.84	[120]
Isobutanol	318.17	-	23.15	[120]
Isobutanol	323.2	-	28.41	[120]
Isopropanol	283.06	-	6.979	[120]
Isopropanol	283.15	-	7.28	[119]
Isopropanol	288.14	-	9.3	[120]
Isopropanol	288.15	-	9.02	[119]
Isopropanol	293.15	-	11.24	[119]
Isopropanol	293.19	-	11.63	[120]
Isopropanol	298.15	-	14.5	[119]
Isopropanol	298.24	-	14.24	[120]
Isopropanol	303.15	-	18.03	[119]
Isopropanol	303.21	-	17.41	[120]
Isopropanol	308.15	-	22.24	[119]
Isopropanol	308.16	-	21.57	[120]
Isopropanol	313.14	-	26.49	[120]
Isopropanol	313.15	-	26.19	[119]
Isopropanol	318.15	-	31.89	[119]
Isopropanol	318.22	-	32.66	[120]
Isopropanol	323.15	-	38.33	[119]
Isopropanol	323.2	-	39.29	[120]
Methanol	283.12	-	21.09	[120]
Methanol	283.15	-	17.19	[119]
Methanol	288.15	-	20.49	[119]
Methanol	288.24	-	22.36	[120]
Methanol	293.15	-	25.36	[119]
Methanol	293.26	-	25.25	[120]
Methanol	298.15	-	30.51	[119]
Methanol	298.17	-	29.69	[120]
Methanol	303.12	-	36.16	[120]
Methanol	303.15	-	38.14	[119]
Methanol	308.14	-	43.88	[120]
Methanol	308.15	-	46.34	[119]
Methanol	313.13	-	53.83	[120]
Methanol	313.15	-	56.86	[119]
Methanol	318.14	-	65.81	[120]
Methanol	318.15	-	69.1	[119]
Methanol	323.12	-	79.69	[120]
Methanol	323.15	-	82.4	[119]
Methyl ethyl ketone	283.14	-	7.832	[120]
Methyl ethyl ketone	288.16	-	9.229	[120]
Methyl ethyl ketone	293.17	-	10.86	[120]
Methyl ethyl ketone	298.16	-	12.57	[120]
Methyl ethyl ketone	303.17	-	14.8	[120]
Methyl ethyl ketone	308.14	-	17.34	[120]
Methyl ethyl ketone	313.16	-	19.97	[120]
Methyl ethyl ketone	318.17	-	22.81	[120]
Methyl ethyl ketone	323.16	-	26.75	[120]
Propyl acetate	283.16	-	1.457	[120]
Propyl acetate	288.24	-	1.737	[120]
Propyl acetate	293.16	-	2.093	[120]
Propyl acetate	298.18	-	2.562	[120]
Propyl acetate	303.16	-	3.11	[120]
Propyl acetate	308.16	-	3.756	[120]
Propyl acetate	313.18	-	4.484	[120]
Propyl acetate	318.16	-	5.41	[120]
Propyl acetate	323.16	-	6.497	[120]
Water	283.15	-	0.0247	[119]
Water	288.15	-	0.0318	[119]
Water	293.15	-	0.0403	[119]
Water	298.15	-	0.0512	[119]
Water	303.15	-	0.0658	[119]
Water	308.15	-	0.0825	[119]
Water	313.15	-	0.1022	[119]
Water	318.15	-	0.1253	[119]
Water	323.15	-	0.1553	[119]

Molecule 3D descriptors

Descriptor	Value
PMI1	630.4278
PMI2	10897.6256
PMI3	10953.6485
NPR1	0.0576
NPR2	0.9949
RadiusOfGyration	5.5738
InertialShapeFactor	0.0016
Eccentricity	0.9983
Asphericity	0.8388
SpherocityIndex	0.0946
PBF	0.7573